Retatrutide

What is retatrutide?

Retatrutide (LY3437943) is a synthetic investigational peptide developed by Eli Lilly. It functions as a triple agonist, simultaneously activating three metabolic receptors: the GLP-1 receptor, the GIP receptor, and the glucagon receptor. It is currently in Phase 3 clinical trials for obesity and metabolic disease and is supplied by Pepta Supply as a lyophilised research compound.

How does retatrutide differ from semaglutide or tirzepatide?

Semaglutide targets only the GLP-1 receptor. Tirzepatide adds GIP receptor activity to GLP-1 agonism, making it a dual agonist. Retatrutide extends this further by also engaging the glucagon receptor, resulting in a triple-agonist profile. The addition of glucagon receptor activity introduces an energy-expenditure component not present in GLP-1 or GLP-1/GIP compounds, which is the subject of significant ongoing pharmacodynamic research.

What receptor targets does retatrutide act on?

Retatrutide simultaneously activates three receptors: the GLP-1 receptor (GLP-1R), which regulates satiety and glucose-stimulated insulin secretion; the GIP receptor (GIPR), which potentiates insulin response and modulates adipose tissue; and the glucagon receptor (GCGR), which influences hepatic energy expenditure and fatty acid oxidation. This triple-receptor mechanism is the basis for its investigation as a metabolic research compound.

What is the molecular structure of retatrutide?

Retatrutide is a 39-amino acid peptide derived from a GIP backbone and coupled to a fatty diacid moiety. The acylation extends its half-life to approximately six days. Its molecular formula is C₂₂₁H₃₄₂N₄₆O₆₈ with a molecular weight of 4,731.4 g/mol and CAS number 2381089-83-2.

Is retatrutide the same as LY3437943?

Yes. LY3437943 is the development code assigned to retatrutide by Eli Lilly. Both names refer to the same investigational compound. You may encounter both designations in published research literature and clinical trial databases.

Research Data

What does the Phase 2 clinical data show for retatrutide?

Phase 2 data published in the New England Journal of Medicine in 2023 reported dose-dependent body weight reductions of approximately 17.5% at 24 weeks and 24.4% at 48 weeks. Extended 68-week data at the highest dose studied recorded reductions of up to 28.7%. A separate Phase 2 trial published in Nature Medicine found reductions in hepatic fat content of up to 82% in subjects with metabolic dysfunction-associated steatotic liver disease. These are research findings from clinical trials and do not constitute claims about the compound's use outside of controlled research settings.

What is the TRIUMPH programme?

TRIUMPH is the Phase 3 clinical development program for retatrutide, currently underway. It investigates retatrutide's effects across obesity, type 2 diabetes, and non-alcoholic fatty liver disease across larger and more diverse study populations than the Phase 2 trials. Data from TRIUMPH will inform any potential regulatory submissions. Pepta Supply provides retatrutide as a research compound and is not affiliated with Eli Lilly or the TRIUMPH trials.

What research areas is retatrutide being studied in?

Current research areas include energy homeostasis and adipose tissue biology, multi-receptor incretin pharmacodynamics, glycemic regulation and insulin sensitivity, hepatic steatosis and fibrosis, cardiovascular metabolic markers, and the comparative pharmacology of mono, dual, and triple agonist incretin compounds.

Ordering and Product Details

What sizes of retatrutide does PeptaSupply offer?

Retatrutide is available in three sizes: 10 mg, 20 mg, and 30 mg. All sizes are supplied as lyophilised powder in sealed vials, with batch documentation accessible via the integrated QR verification system.

What form is the product supplied in?

Retatrutide from Pepta Supply is supplied as a lyophilised (freeze-dried) powder. This form provides stability during storage and transport. Reconstitution with bacteriostatic water is standard practice for research preparation, following laboratory protocols appropriate to the intended research application.

What is the purity of Pepta Supply's retatrutide?

Pepta Supply's retatrutide carries a purity of 99% or above, confirmed by independent third-party HPLC analysis. Each batch has its own Certificate of Analysis, accessible through the batch verification system at peptasupply.com/v/ or by scanning the QR code on the vial.

Does Pepta Supply test its retatrutide independently?

Yes. Every batch of retatrutide undergoes independent analytical testing by a third-party laboratory using high-performance liquid chromatography (HPLC). This confirms both compound identity and purity. The test data is not self-reported; it is produced externally and linked directly to each vial through Pepta Supply's batch verification system.

Batch Verification

How does Pepta Supply's batch verification system work?

Each vial of retatrutide carries a unique batch identifier. Scan the QR code on the vial or visit peptasupply.com/v/ and enter the batch number. You will be taken directly to the batch-specific documentation, which includes the HPLC test report and Certificate of Analysis for that exact unit. This gives researchers access to analytical data before and after purchase.

Can I access the Certificate of Analysis before ordering?

Yes. Batch documentation is publicly accessible through the verification system. You do not need to complete a purchase to check the analytical data associated with available batches.

Why is batch-level traceability important for research?

Batch-level traceability allows researchers to document exactly which material was used in a given experiment, cross-reference analytical data, and maintain reproducibility across studies. Without it, there is no reliable way to confirm that two vials from different orders contain the same compound at the same purity. Pepta Supply's QR-linked documentation provides this record at the individual unit level.

Shipping and Delivery

Where does Pepta Supply ship retatrutide?

Pepta Supply ships across the European Union and internationally. Orders placed before 3:00 PM (Monday to Friday) are dispatched the same day. Most EU destinations receive orders within 1 to 3 business days. Delivery to Spain and Italy typically takes 3 to 6 business days.

How is retatrutide packaged for delivery?

All orders are discreetly packaged to ensure product integrity during transit. Retatrutide, as a lyophilized powder, maintains stability during standard shipping at ambient temperatures. Upon receipt, transfer to refrigerated storage at 2 to 8 degrees Celsius is recommended.

Is free shipping available?

Yes. Pepta Supply offers free shipping on orders over 150 euros. For orders below this threshold, standard shipping rates apply at checkout.

Compliance and Intended Use

Is retatrutide from Pepta Supply approved for human use?

No. Retatrutide is an investigational compound currently in Phase 3 clinical trials. It has not received regulatory approval for human use in any jurisdiction. Pepta Supply supplies retatrutide exclusively for qualified scientific and laboratory research. It is not intended for human consumption, therapeutic, diagnostic, or clinical use.

Who can purchase retatrutide from Pepta Supply?

Retatrutide is supplied to qualified professionals in controlled laboratory environments. By purchasing, buyers confirm they are acquiring the compound for legitimate scientific research and accept full responsibility for compliance with applicable laws and regulations in their country.

Is retatrutide legal to purchase in Europe for research?

Regulations governing research compounds vary by country. Buyers are solely responsible for determining whether purchase and use of retatrutide is permitted under the laws of their country or jurisdiction. Pepta Supply does not provide legal advice and accepts no liability for misuse or non-compliant use.